Histological and histochemical aspects of the dentin-pulp complex in offsprings of rats treated with fluoxetine during pregnancy and lactation

Abstract

Aim:This study aimed to analyze histological aspects of the dentin-pulp complex in rats neonates treated with fluoxetine during pregnancy and lactation.

Methodology: For this purpose were used first molars of 24 Wistar rat pups, 25 days old-aged, divided into 4 groups: PCG and PCGL whose mothers positive controls received 0.9% NaCl (oral) during gestation and  gestacion/lactation, respectively; FG and FGL both mothers received fluoxetine at 20 mg / kg (oral) during pregnancy and gestation/lactation, respectively. The animals were anesthetized, maxillaries removed and fixed in 4% formaldehyde, decalcified in EDTA and processed conventionally for light microscopy. Paraffin sections were stained by Hematoxylin and Eosin, Masson’s Trichromatic and Pricosirius Red.

Results: There was no evidence of structural and histochemical changes in the pulp-dentin complex in the groups studied.

Conclusions: Therefore, we could conclude that the fluoxetine in 20 mg/kg dosage, administrated during pregnancy and lactation, did not interfered in the dentin-pulp complex development in offsprings of rats when analyzed in the age of 25 days.

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Author Biographies

Jessyca França, Federal University of Pernambuco, Recife, Pernambuco

PhD student at the Dentistry Graduate Program at the Federal University of Pernambuco 

Eduardo Barbosa, Federal University of Pernambuco, Recife, Pernambuco

MSc at the Dentistry Graduate Program at the Federal University of Pernambuco

Published
2020-10-26
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Original Articles
Keywords:
dental development, depression, fluoexetine, pregnancy, rats
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How to Cite
França, J., & Barbosa, E. (2020). Histological and histochemical aspects of the dentin-pulp complex in offsprings of rats treated with fluoxetine during pregnancy and lactation. Giornale Italiano Di Endodonzia, 34(2). https://doi.org/10.32067/GIE.2020.34.02.10