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Dentinal tubule penetration of bioceramic-based versus epoxy resin-based root canal sealers: a systematic review and meta-analysis

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An ideal endodontic treatment involves filling the root canal system with a sealer that penetrates the dentinal tubules and remains intact. Hence, this systematic review aimed to appraise and analyse the dentinal tubule penetration of bioceramic-based and epoxy resin-based root canal sealers. 

Articles published between January 1990 and March 2022 were searched in seven online databases (Google Scholar, PubMed, Web of Science – Core collection, Scopus, Cochrane Library, EBSCO, and Open Grey). Only in-vitro studies evaluating dentinal tubule penetration of bioceramic-based and epoxy resin-based sealers were selected. The OHAT risk of bias (RoB) tool was employed to analyse the RoB of each article. A two-arm meta-analysis based on the DerSimonian-Laird random-effects model was used to assess the standardised weighted mean differences in dentinal tubule penetration for both sealer types. 

Although bioceramic-based root canal sealers exhibit inferior dentinal tubule penetration than epoxy resin-based sealers, future well-designed studies with standardised evaluation tools and a more control of confounding variables should be conducted.

How to Cite

Lin, G. S. S., Chan, D. Z. K., Leong, J. Z., Kan, I. Z., Xuan, W. M., & Tee, V. (2022). Dentinal tubule penetration of bioceramic-based versus epoxy resin-based root canal sealers: a systematic review and meta-analysis. Giornale Italiano Di Endodonzia, 36(2). https://doi.org/10.32067/GIE.2021.35.02.60