Dentinal tubule penetration of bioceramic-based versus epoxy resin-based root canal sealers: a systematic review and meta-analysis


Submitted: 3 February 2022
Accepted: 26 May 2022
Published: 1 July 2022
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Authors

  • Galvin Sim Siang Lin Department of Dental Materials, Faculty of Dentistry, Asian Institute of Medicine, Science and Technology (AIMST) University, 08100, Bedong, Kedah, Malaysia. https://orcid.org/0000-0002-3996-5470
  • Daryl Zhun Kit Chan Department of Dental Materials, Faculty of Dentistry, Asian Institute of Medicine, Science and Technology (AIMST) University, 08100, Bedong, Kedah, Malaysia.
  • Jia Zheng Leong Petaling Dental Clinic, Ministry of Health Malaysia, 71600, Kuala Klawang, Negeri Sembilan, Malaysia.
  • Ing Zheng Kan Bukit Minyak Dental Clinic, Ministry of Health Malaysia, 14000, Bukit Mertajam, Penang, Malaysia.
  • Wong Mun Xuan Pertang Dental Clinic, Ministry of Health Malaysia, 72300, Jelebu, Negeri Sembilan, Malaysia.
  • Vincent Tee Department of Internal Medicine, School of Medical Sciences, University Sains Malaysia, Health Campus, 16150, Kubang Kerian, Kelantan, Malaysia.

An ideal endodontic treatment involves filling the root canal system with a sealer that penetrates the dentinal tubules and remains intact. Hence, this systematic review aimed to appraise and analyse the dentinal tubule penetration of bioceramic-based and epoxy resin-based root canal sealers. 

Articles published between January 1990 and March 2022 were searched in seven online databases (Google Scholar, PubMed, Web of Science – Core collection, Scopus, Cochrane Library, EBSCO, and Open Grey). Only in-vitro studies evaluating dentinal tubule penetration of bioceramic-based and epoxy resin-based sealers were selected. The OHAT risk of bias (RoB) tool was employed to analyse the RoB of each article. A two-arm meta-analysis based on the DerSimonian-Laird random-effects model was used to assess the standardised weighted mean differences in dentinal tubule penetration for both sealer types. 

Although bioceramic-based root canal sealers exhibit inferior dentinal tubule penetration than epoxy resin-based sealers, future well-designed studies with standardised evaluation tools and a more control of confounding variables should be conducted.


Lin, G. S. S., Chan, D. Z. K., Leong, J. Z., Kan, I. Z., Xuan, W. M., & Tee, V. (2022). Dentinal tubule penetration of bioceramic-based versus epoxy resin-based root canal sealers: a systematic review and meta-analysis. Giornale Italiano Di Endodonzia, 35. https://doi.org/10.32067/GIE.2021.35.02.60

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